Prerequisite
– the Display chronic hazard labels option must be activated
(see Activate an option).

Each product is automatically analyzed on the basis of the substances listed on the SDS.

To access the Substances List :
– Applications menu > Chemicals > Substances

There are two lists:

• Substances declared in the Quarks Safety database for which a regulatory watch exists
• The substances making up the products registered in the inventory.

Characteristics column:
Substances are displayed by CAS number.
Colored dots indicate the hazardousness of the substance.

When hovered over, the sticker displays details of the substance and its hazard characteristics, analyzed according to hazard statements.

• Specifications shown in light gray indicate non-hazardous substances.
• Features shown in dark grayindicate substances that present ambiguities, which Quarks Safety can help you resolve, or substances not present in the database supplied and maintained by Quarks Safety.

Clicking on a substance designation opens a detailed data sheet in the side panel.

Organized into tabs, the data sheet provides all technical and regulatory information on the substance.

• General tab:
  Displays, where available, product carcinogenicity data, exposure limit values, biological exposure indices, table of occupational diseases and physico-chemical properties.
• Classification tab:
  Displays the elements of hazard classification, in current and historical French and European regulations (depending on the options selected).
  Concentration: Select the substance concentration to automatically display the associated hazard analysis; hazard and precautionary statements are displayed. Quarks Safety has created the CMR symbol to distinguish CMR substances at a glance from those classified under GHS 07.
• Citations tab:
  This tab details, when the substance is concerned, the chemical family or families as well as any regulations. In the latter case, a link to Voir sur le site de : gives access to the source.

On the dashboard, regulatory watches set up in the platform are indicated as soon as there is a regulatory update.

You can update the regulatory watch directly from the substance sheet at any time by clicking on .

Data on the carcinogenicity of substances

Information on the carcinogenicity of substances comes from four main scientific sources, depending on the geographical area:

1. At European Union level :

• CLP Annex VI (Harmonized Classification Table) :
  • H340: Mutagen 1, 1A or 1B (known or suspected).
  • H341: Mutagen 2 (suspected)
  • H350, H350i: Carcinogenic 1, 1A or 1B (known or suspected)
  • H351: Carcinogen 2 (suspected)
  • H360, H360F, H360D, H360FD, H360Fd, H360fD: Reprotoxic 1, 1A or 1B (known or suspected)
  • H361, H361f, H361d, H361fd: Reprotoxic 2 (suspected).
  • H362: Dangerous for or via breast-feeding

• ECHA website (for auto-classified substances) :
  • CP: Potential Carcinogen.
  • MP: Potential Mutagen.
  • PR: Potential Reprotoxic.
  • LP: Toxic substance with potential effects on or via lactation.

2. International: IARC (International Agency for Research on Cancer)

IARC is a cancer research agency of the World Health Organization (WHO), based in Lyon. In English, it is known as the International Agency for Research on Cancer (IARC). IARC classifies substances according to their carcinogenicity to humans in the following categories:

• Group 1: Carcinogenic to humans (known or certain carcinogen).
• Group 2A: Probably carcinogenic to humans.
• Group 2B: Agent possibly carcinogenic to humans (possible carcinogen).
• Group 3: Agent unclassifiable as to carcinogenicity in humans.

3. In the United States: ACGIH (American Conference of Governmental Industrial Hygienists)

ACGIH is an American non-governmental organization made up of industrial hygienists from US government agencies. It develops and publishes recommended exposure standards for chemicals and physical agents, as well as a list of biological exposure indices. The ACGIH classifies chemicals or agents into the following five categories:

• A1: Confirmed human carcinogen.
• A2: Suspected human carcinogen.
• A3: Confirmed animal carcinogen with unknown relevance to humans.
• A4: Not classifiable as a human carcinogen.
• A5: Presumed not carcinogenic to humans.

4. In California: Proposition 65 (Cal. Prop. 65)

California’s Proposition 65, also known as Cal. Prop. 65 Safe Drinking Water and Toxic Enforcement Act of 1986. This law is regularly updated by the California Office of Environmental Health Hazard Assessment (OEHHA). It classifies substances into the following categories:

• Carcinogen: Agent capable of causing cancer.
• Developmental toxicity: When chemical exposure of the mother before or during pregnancy, or of the father before conception, results in adverse effects on the developing embryo or fetus.
• Male reproductive toxicity: When exposure to a chemical damages a man’s ability to procreate, the damage can affect any organ or body part involved in reproduction, including the gonads and parts of the nervous and endocrine systems that influence reproduction.
• Female reproductive toxicity: When exposure to a chemical damages a woman’s ability to conceive, breastfeed or carry a pregnancy to term. Damage can affect any organ or body part involved in reproduction, including the gonads and parts of the nervous and endocrine systems that influence reproduction.